Drug interactions
Lonafarnib + Loratadine
Severity: Minor
Lonafarnib and Loratadine: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Lonafarnib is a weak P-gp inhibitor and may slightly increase loratadine exposure. Clinical consequences are expected to be minimal because loratadine has a wide therapeutic index.
What this interaction means in plain words
Lonafarnib and Loratadine have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Lonafarnib belongs to Miscellaneous; Loratadine belongs to Respiratory.
Why it happens
Weak inhibition of P-glycoprotein by lonafarnib reduces loratadine efflux.
What to do
No action is generally needed; watch for increased drowsiness. Lower the loratadine dose if adverse effects occur.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Loratadine
- Acrivastine + Loratadine Moderate
- Amobarbital + Loratadine Moderate
- Fentanyl + Loratadine Moderate
- Isocarboxazid + Loratadine Moderate
- Levoketoconazole + Loratadine Moderate
- Loratadine + Mavacamten Moderate
Other interactions of Lonafarnib
- Alfuzosin + Lonafarnib Contraindicated
- Amobarbital + Lonafarnib Contraindicated
- Apalutamide + Lonafarnib Contraindicated
- Bosentan + Lonafarnib Contraindicated
- Carbamazepine + Lonafarnib Contraindicated
- Clarithromycin + Lonafarnib Contraindicated
Frequently asked questions
Can I take Lonafarnib with Loratadine?
MediHelp rates the interaction as minor. Lonafarnib and Loratadine have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Lonafarnib is a weak P-gp inhibitor and may slightly increase loratadine exposure. Clinical consequences are expected to be minimal because loratadine has a wide therapeutic index.
How serious is the interaction between Lonafarnib and Loratadine?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: No action is generally needed; watch for increased drowsiness. Lower the loratadine dose if adverse effects occur.
What other medicines interact with Loratadine?
MediHelp also lists interactions of Loratadine with, for example, Acrivastine, Amobarbital, Fentanyl. The full list is on the Loratadine page.
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