Drug interactions
Lonafarnib + Methylprednisolone
Severity: Minor
Lonafarnib and Methylprednisolone: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Lonafarnib is a sensitive CYP3A substrate, and the legacy direction is reversed because methylprednisolone is not a recognized meaningful CYP3A inhibitor. Any effect on lonafarnib exposure is not well established clinically.
What this interaction means in plain words
Lonafarnib and Methylprednisolone have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Lonafarnib belongs to Miscellaneous; Methylprednisolone belongs to Endocrine.
Why it happens
Methylprednisolone is a weak CYP3A substrate and not a clinically relevant inhibitor, so a pharmacokinetic effect on lonafarnib is not established.
What to do
No specific adjustment is required; monitor for lonafarnib adverse effects such as gastrointestinal toxicity if used together.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Methylprednisolone
- Bcg vaccine live + Methylprednisolone Contraindicated
- Measles mumps and rubella vaccine live + Methylprednisolone Contraindicated
- Measles mumps rubella and varicella vaccine live + Methylprednisolone Contraindicated
- Measles vaccine + Methylprednisolone Contraindicated
- Methylprednisolone + Mifepristone Contraindicated
- Methylprednisolone + Rubella vaccine Contraindicated
Other interactions of Lonafarnib
- Alfuzosin + Lonafarnib Contraindicated
- Amobarbital + Lonafarnib Contraindicated
- Apalutamide + Lonafarnib Contraindicated
- Bosentan + Lonafarnib Contraindicated
- Carbamazepine + Lonafarnib Contraindicated
- Clarithromycin + Lonafarnib Contraindicated
Frequently asked questions
Can I take Lonafarnib with Methylprednisolone?
MediHelp rates the interaction as minor. Lonafarnib and Methylprednisolone have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Lonafarnib is a sensitive CYP3A substrate, and the legacy direction is reversed because methylprednisolone is not a recognized meaningful CYP3A inhibitor. Any effect on lonafarnib exposure is not well established clinically.
How serious is the interaction between Lonafarnib and Methylprednisolone?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: No specific adjustment is required; monitor for lonafarnib adverse effects such as gastrointestinal toxicity if used together.
What other medicines interact with Methylprednisolone?
MediHelp also lists interactions of Methylprednisolone with, for example, Bcg vaccine live, Measles mumps and rubella vaccine live, Measles mumps rubella and varicella vaccine live. The full list is on the Methylprednisolone page.
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