Drug interactions
Lonafarnib + Micafungin
Severity: Minor
Lonafarnib and Micafungin: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Lonafarnib is a sensitive CYP3A substrate. Micafungin is at most a weak CYP3A inhibitor, so any increase in lonafarnib exposure would be small.
What this interaction means in plain words
Lonafarnib and Micafungin have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Lonafarnib belongs to Miscellaneous; Micafungin belongs to Anti Fungals.
Why it happens
Weak CYP3A4 inhibition by micafungin could slightly reduce lonafarnib clearance.
What to do
No dose change is generally needed; monitor for lonafarnib adverse effects such as gastrointestinal toxicity and palpitations or syncope.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Micafungin
- Lomitapide + Micafungin Moderate
- Micafungin + Saccharomyces boulardii Moderate
- Micafungin + Sirolimus Moderate
- Avapritinib + Micafungin Minor
- Finerenone + Micafungin Minor
- Isavuconazonium + Micafungin Minor
Other interactions of Lonafarnib
- Alfuzosin + Lonafarnib Contraindicated
- Amobarbital + Lonafarnib Contraindicated
- Apalutamide + Lonafarnib Contraindicated
- Bosentan + Lonafarnib Contraindicated
- Carbamazepine + Lonafarnib Contraindicated
- Clarithromycin + Lonafarnib Contraindicated
Frequently asked questions
Can I take Lonafarnib with Micafungin?
MediHelp rates the interaction as minor. Lonafarnib and Micafungin have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Lonafarnib is a sensitive CYP3A substrate. Micafungin is at most a weak CYP3A inhibitor, so any increase in lonafarnib exposure would be small.
How serious is the interaction between Lonafarnib and Micafungin?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: No dose change is generally needed; monitor for lonafarnib adverse effects such as gastrointestinal toxicity and palpitations or syncope.
What other medicines interact with Micafungin?
MediHelp also lists interactions of Micafungin with, for example, Lomitapide, Saccharomyces boulardii, Sirolimus. The full list is on the Micafungin page.
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