Drug interactions
Lonafarnib + Mirtazapine
Severity: Moderate
Lonafarnib and Mirtazapine: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Lonafarnib is a sensitive CYP3A substrate, and mirtazapine is a weak CYP3A inhibitor in some reports, so lonafarnib exposure could increase. The effect of lonafarnib on QT is not well defined, so arrhythmia is a theoretical concern.
What this interaction means in plain words
Lonafarnib and Mirtazapine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Lonafarnib belongs to Miscellaneous; Mirtazapine belongs to Central Nervous System.
Why it happens
Possible weak CYP3A inhibition by mirtazapine reducing lonafarnib clearance.
What to do
If the combination is necessary, keep lonafarnib at the starting dose without escalation and monitor for gastrointestinal toxicity and palpitations or syncope.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Mirtazapine
- Isocarboxazid + Mirtazapine Contraindicated
- Mirtazapine + Phenelzine Contraindicated
- Mirtazapine + Pimozide Contraindicated
- Mirtazapine + Procarbazine Contraindicated
- Mirtazapine + Rasagiline Contraindicated
- Mirtazapine + Selegiline Contraindicated
Other interactions of Lonafarnib
- Alfuzosin + Lonafarnib Contraindicated
- Amobarbital + Lonafarnib Contraindicated
- Apalutamide + Lonafarnib Contraindicated
- Bosentan + Lonafarnib Contraindicated
- Carbamazepine + Lonafarnib Contraindicated
- Clarithromycin + Lonafarnib Contraindicated
Frequently asked questions
Can I take Lonafarnib with Mirtazapine?
MediHelp rates the interaction as moderate. Lonafarnib and Mirtazapine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Lonafarnib is a sensitive CYP3A substrate, and mirtazapine is a weak CYP3A inhibitor in some reports, so lonafarnib exposure could increase. The effect of lonafarnib on QT is not well defined, so arrhythmia is a theoretical concern.
How serious is the interaction between Lonafarnib and Mirtazapine?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: If the combination is necessary, keep lonafarnib at the starting dose without escalation and monitor for gastrointestinal toxicity and palpitations or syncope.
What other medicines interact with Mirtazapine?
MediHelp also lists interactions of Mirtazapine with, for example, Isocarboxazid, Phenelzine, Pimozide. The full list is on the Mirtazapine page.
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