Drug interactions
Lonafarnib + Nevirapine
Severity: Moderate
Lonafarnib and Nevirapine: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Lonafarnib is a sensitive CYP3A substrate, so CYP3A modulators change its exposure. Nevirapine is a CYP3A inducer, so the net effect is more likely reduced lonafarnib levels and diminished effect, not increased exposure. The interaction is unclear and not well studied.
What this interaction means in plain words
Lonafarnib and Nevirapine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Lonafarnib belongs to Miscellaneous; Nevirapine belongs to Anti Virals.
Why it happens
Nevirapine is a CYP3A4 inducer and substrate that may alter lonafarnib metabolism, but the direction and size of the effect are not established.
What to do
Monitor clinical response to lonafarnib and for adverse effects including palpitations or syncope. Adjust the dose according to labeling and tolerability.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Nevirapine
- Elbasvir / grazoprevir + Nevirapine Contraindicated
- Nevirapine + Ranolazine Contraindicated
- Nevirapine + St john's wort Contraindicated
- Abemaciclib + Nevirapine Major
- Acalabrutinib + Nevirapine Major
- Amobarbital + Nevirapine Major
Other interactions of Lonafarnib
- Alfuzosin + Lonafarnib Contraindicated
- Amobarbital + Lonafarnib Contraindicated
- Apalutamide + Lonafarnib Contraindicated
- Bosentan + Lonafarnib Contraindicated
- Carbamazepine + Lonafarnib Contraindicated
- Clarithromycin + Lonafarnib Contraindicated
Frequently asked questions
Can I take Lonafarnib with Nevirapine?
MediHelp rates the interaction as moderate. Lonafarnib and Nevirapine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Lonafarnib is a sensitive CYP3A substrate, so CYP3A modulators change its exposure. Nevirapine is a CYP3A inducer, so the net effect is more likely reduced lonafarnib levels and diminished effect, not increased exposure. The interaction is unclear and not well studied.
How serious is the interaction between Lonafarnib and Nevirapine?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor clinical response to lonafarnib and for adverse effects including palpitations or syncope. Adjust the dose according to labeling and tolerability.
What other medicines interact with Nevirapine?
MediHelp also lists interactions of Nevirapine with, for example, Elbasvir / grazoprevir, Ranolazine, St john's wort. The full list is on the Nevirapine page.
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