Drug interactions
Lonafarnib + Palbociclib
Severity: Moderate
Lonafarnib and Palbociclib: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Palbociclib may weakly inhibit CYP3A4 and raise levels of lonafarnib, a sensitive CYP3A substrate. Higher lonafarnib exposure may increase its adverse effects, including gastrointestinal toxicity and possible QT effects.
What this interaction means in plain words
Lonafarnib and Palbociclib can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Lonafarnib belongs to Miscellaneous; Palbociclib belongs to Oncology.
Why it happens
Palbociclib inhibits CYP3A4, reducing lonafarnib metabolism.
What to do
Monitor for lonafarnib toxicity and cardiac symptoms, and consider ECG monitoring. Keep lonafarnib at the lowest recommended dose.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Palbociclib
Other interactions of Lonafarnib
- Alfuzosin + Lonafarnib Contraindicated
- Amobarbital + Lonafarnib Contraindicated
- Apalutamide + Lonafarnib Contraindicated
- Bosentan + Lonafarnib Contraindicated
- Carbamazepine + Lonafarnib Contraindicated
- Clarithromycin + Lonafarnib Contraindicated
Frequently asked questions
Can I take Lonafarnib with Palbociclib?
MediHelp rates the interaction as moderate. Lonafarnib and Palbociclib can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Palbociclib may weakly inhibit CYP3A4 and raise levels of lonafarnib, a sensitive CYP3A substrate. Higher lonafarnib exposure may increase its adverse effects, including gastrointestinal toxicity and possible QT effects.
How serious is the interaction between Lonafarnib and Palbociclib?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor for lonafarnib toxicity and cardiac symptoms, and consider ECG monitoring. Keep lonafarnib at the lowest recommended dose.
What other medicines interact with Palbociclib?
MediHelp also lists interactions of Palbociclib with, for example, Apalutamide, Atazanavir, Carbamazepine. The full list is on the Palbociclib page.
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