Drug interactions
Lonafarnib + Ranolazine
Severity: Contraindicated
Lonafarnib and Ranolazine: contraindicated interaction.
Last updated Sources: US FDA label
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Lonafarnib is a strong CYP3A inhibitor and may considerably increase ranolazine exposure. Ranolazine is a weak CYP3A inhibitor and may in turn raise lonafarnib levels, with the added risk of QT prolongation and toxicity.
What this interaction means in plain words
Lonafarnib and Ranolazine are not normally used together. Taking them at the same time is expected to cause harm or make one of them unsafe, so a different medicine is usually chosen for one of the two.
Lonafarnib belongs to Miscellaneous; Ranolazine belongs to Cardiovascular.
Why it happens
Lonafarnib inhibits CYP3A4 metabolism of ranolazine, and ranolazine weakly inhibits CYP3A4 metabolism of lonafarnib.
What to do
Avoid the combination, as strong CYP3A inhibitors are contraindicated with ranolazine. Use an alternative antianginal agent.
What to ask your pharmacist
- Is there an alternative to one of these two medicines for me?
- If both are essential, who is monitoring me and how often?
- Which symptoms mean I should stop and seek help straight away?
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References
Other interactions of Ranolazine
- Adagrasib + Ranolazine Contraindicated
- Amobarbital + Ranolazine Contraindicated
- Apalutamide + Ranolazine Contraindicated
- Butabarbital + Ranolazine Contraindicated
- Carbamazepine + Ranolazine Contraindicated
- Clarithromycin + Ranolazine Contraindicated
Other interactions of Lonafarnib
- Alfuzosin + Lonafarnib Contraindicated
- Amobarbital + Lonafarnib Contraindicated
- Apalutamide + Lonafarnib Contraindicated
- Bosentan + Lonafarnib Contraindicated
- Carbamazepine + Lonafarnib Contraindicated
- Clarithromycin + Lonafarnib Contraindicated
Frequently asked questions
Can I take Lonafarnib with Ranolazine?
MediHelp rates the interaction as contraindicated. Lonafarnib and Ranolazine are not normally used together. Taking them at the same time is expected to cause harm or make one of them unsafe, so a different medicine is usually chosen for one of the two. Lonafarnib is a strong CYP3A inhibitor and may considerably increase ranolazine exposure. Ranolazine is a weak CYP3A inhibitor and may in turn raise lonafarnib levels, with the added risk of QT prolongation and toxicity.
How serious is the interaction between Lonafarnib and Ranolazine?
MediHelp rates it contraindicated, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid the combination, as strong CYP3A inhibitors are contraindicated with ranolazine. Use an alternative antianginal agent.
What other medicines interact with Ranolazine?
MediHelp also lists interactions of Ranolazine with, for example, Adagrasib, Amobarbital, Apalutamide. The full list is on the Ranolazine page.
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