Drug interactions
Lonafarnib + Risperidone
Severity: Minor
Lonafarnib and Risperidone: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Risperidone is not a recognized CYP3A4 inhibitor, so a meaningful rise in lonafarnib levels is not expected from the stated mechanism. Any concern is theoretical and would relate to lonafarnib's own CYP3A interactions.
What this interaction means in plain words
Lonafarnib and Risperidone have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Lonafarnib belongs to Miscellaneous; Risperidone belongs to Central Nervous System.
Why it happens
No established mechanism; risperidone has negligible CYP3A4 inhibition.
What to do
No dose change is needed. Monitor for arrhythmia symptoms such as palpitations or syncope.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Risperidone
- Ibutilide + Risperidone Contraindicated
- Risperidone + Vandetanib Contraindicated
- Adagrasib + Risperidone Major
- Amiodarone + Risperidone Major
- Amisulpride + Risperidone Major
- Amoxapine + Risperidone Major
Other interactions of Lonafarnib
- Alfuzosin + Lonafarnib Contraindicated
- Amobarbital + Lonafarnib Contraindicated
- Apalutamide + Lonafarnib Contraindicated
- Bosentan + Lonafarnib Contraindicated
- Carbamazepine + Lonafarnib Contraindicated
- Clarithromycin + Lonafarnib Contraindicated
Frequently asked questions
Can I take Lonafarnib with Risperidone?
MediHelp rates the interaction as minor. Lonafarnib and Risperidone have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Risperidone is not a recognized CYP3A4 inhibitor, so a meaningful rise in lonafarnib levels is not expected from the stated mechanism. Any concern is theoretical and would relate to lonafarnib's own CYP3A interactions.
How serious is the interaction between Lonafarnib and Risperidone?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: No dose change is needed. Monitor for arrhythmia symptoms such as palpitations or syncope.
What other medicines interact with Risperidone?
MediHelp also lists interactions of Risperidone with, for example, Ibutilide, Vandetanib, Adagrasib. The full list is on the Risperidone page.
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