Drug interactions
Lonafarnib + Ropivacaine
Severity: Minor
Lonafarnib and Ropivacaine: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Lonafarnib inhibits CYP3A4, a minor pathway for ropivacaine, so a small increase in ropivacaine exposure is possible. Clinical significance is likely limited.
What this interaction means in plain words
Lonafarnib and Ropivacaine have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Lonafarnib belongs to Miscellaneous; Ropivacaine belongs to Central Nervous System.
Why it happens
Lonafarnib inhibits CYP3A4, slightly reducing ropivacaine clearance.
What to do
No routine adjustment; avoid prolonged infusions and monitor for signs of local anesthetic toxicity.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Ropivacaine
- Bupivacaine implant + Ropivacaine Major
- Bupivacaine liposome + Ropivacaine Major
- Amlodipine-benazepril + Ropivacaine Moderate
- Benazepril + Ropivacaine Moderate
- Captopril-hydrochlorothiazide + Ropivacaine Moderate
- Captopril + Ropivacaine Moderate
Other interactions of Lonafarnib
- Alfuzosin + Lonafarnib Contraindicated
- Amobarbital + Lonafarnib Contraindicated
- Apalutamide + Lonafarnib Contraindicated
- Bosentan + Lonafarnib Contraindicated
- Carbamazepine + Lonafarnib Contraindicated
- Clarithromycin + Lonafarnib Contraindicated
Frequently asked questions
Can I take Lonafarnib with Ropivacaine?
MediHelp rates the interaction as minor. Lonafarnib and Ropivacaine have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Lonafarnib inhibits CYP3A4, a minor pathway for ropivacaine, so a small increase in ropivacaine exposure is possible. Clinical significance is likely limited.
How serious is the interaction between Lonafarnib and Ropivacaine?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: No routine adjustment; avoid prolonged infusions and monitor for signs of local anesthetic toxicity.
What other medicines interact with Ropivacaine?
MediHelp also lists interactions of Ropivacaine with, for example, Bupivacaine implant, Bupivacaine liposome, Amlodipine-benazepril. The full list is on the Ropivacaine page.
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