Drug interactions
Lonafarnib + Vortioxetine
Severity: Moderate
Lonafarnib and Vortioxetine: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Lonafarnib is a strong CYP3A inhibitor and may raise vortioxetine exposure. Adverse effects such as nausea and serotonergic symptoms may become more likely.
What this interaction means in plain words
Lonafarnib and Vortioxetine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Lonafarnib belongs to Miscellaneous; Vortioxetine belongs to Central Nervous System.
Why it happens
Lonafarnib inhibits CYP3A4, reducing the secondary metabolic clearance of vortioxetine.
What to do
Monitor for vortioxetine adverse effects and reduce the dose if they appear. Reassess the dose when lonafarnib is discontinued.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Vortioxetine
- Isocarboxazid + Vortioxetine Contraindicated
- Linezolid + Vortioxetine Contraindicated
- Methylene blue + Vortioxetine Contraindicated
- Phenelzine + Vortioxetine Contraindicated
- Rasagiline + Vortioxetine Contraindicated
- Selegiline transdermal + Vortioxetine Contraindicated
Other interactions of Lonafarnib
- Alfuzosin + Lonafarnib Contraindicated
- Amobarbital + Lonafarnib Contraindicated
- Apalutamide + Lonafarnib Contraindicated
- Bosentan + Lonafarnib Contraindicated
- Carbamazepine + Lonafarnib Contraindicated
- Clarithromycin + Lonafarnib Contraindicated
Frequently asked questions
Can I take Lonafarnib with Vortioxetine?
MediHelp rates the interaction as moderate. Lonafarnib and Vortioxetine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Lonafarnib is a strong CYP3A inhibitor and may raise vortioxetine exposure. Adverse effects such as nausea and serotonergic symptoms may become more likely.
How serious is the interaction between Lonafarnib and Vortioxetine?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor for vortioxetine adverse effects and reduce the dose if they appear. Reassess the dose when lonafarnib is discontinued.
What other medicines interact with Vortioxetine?
MediHelp also lists interactions of Vortioxetine with, for example, Isocarboxazid, Linezolid, Methylene blue. The full list is on the Vortioxetine page.
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