Drug interactions
Loperamide + Trazodone
Severity: Minor
Loperamide and Trazodone: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Trazodone has no established effect that lowers loperamide levels. Trazodone can prolong QT, so the more relevant concern is additive cardiac risk with high-dose loperamide.
What this interaction means in plain words
Loperamide and Trazodone have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Loperamide belongs to Gastrointestinal Tract; Trazodone belongs to Central Nervous System.
Why it happens
No established pharmacokinetic mechanism; possible additive QT effect.
What to do
Use loperamide at labeled doses. Check an ECG if other QT-prolonging factors are present.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Loperamide
Other interactions of Trazodone
- Arsenic trioxide + Trazodone Contraindicated
- Ibutilide + Trazodone Contraindicated
- Isocarboxazid + Trazodone Contraindicated
- Levoketoconazole + Trazodone Contraindicated
- Methylene blue + Trazodone Contraindicated
- Phenelzine + Trazodone Contraindicated
Frequently asked questions
Can I take Loperamide with Trazodone?
MediHelp rates the interaction as minor. Loperamide and Trazodone have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Trazodone has no established effect that lowers loperamide levels. Trazodone can prolong QT, so the more relevant concern is additive cardiac risk with high-dose loperamide.
How serious is the interaction between Loperamide and Trazodone?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Use loperamide at labeled doses. Check an ECG if other QT-prolonging factors are present.
What other medicines interact with Loperamide?
MediHelp also lists interactions of Loperamide with, for example, Amiodarone, Amisulpride, Anagrelide. The full list is on the Loperamide page.
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