Drug interactions
Lopinavir + Lurasidone
Severity: Contraindicated
Lopinavir and Lurasidone: contraindicated interaction.
Last updated Sources: US FDA label
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Lopinavir is co-formulated with ritonavir, a strong CYP3A4 inhibitor, and is expected to raise lurasidone exposure considerably. This increases the risk of sedation, extrapyramidal symptoms and other dose-related toxicity. The combination is contraindicated.
What this interaction means in plain words
Lopinavir and Lurasidone are not normally used together. Taking them at the same time is expected to cause harm or make one of them unsafe, so a different medicine is usually chosen for one of the two.
Lopinavir belongs to Anti Virals; Lurasidone belongs to Central Nervous System.
Why it happens
Ritonavir-boosted lopinavir inhibits CYP3A4-mediated metabolism of lurasidone.
What to do
Do not coadminister; choose an antipsychotic less dependent on CYP3A4 or a different antiretroviral.
What to ask your pharmacist
- Is there an alternative to one of these two medicines for me?
- If both are essential, who is monitoring me and how often?
- Which symptoms mean I should stop and seek help straight away?
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References
Other interactions of Lurasidone
- Apalutamide + Lurasidone Contraindicated
- Atazanavir + Lurasidone Contraindicated
- Carbamazepine + Lurasidone Contraindicated
- Clarithromycin + Lurasidone Contraindicated
- Cobicistat + Lurasidone Contraindicated
- Conivaptan + Lurasidone Contraindicated
Other interactions of Lopinavir
- Alfuzosin + Lopinavir Contraindicated
- Avanafil + Lopinavir Contraindicated
- Cisapride + Lopinavir Contraindicated
- Dronedarone + Lopinavir Contraindicated
- Eletriptan + Lopinavir Contraindicated
- Eplerenone + Lopinavir Contraindicated
Frequently asked questions
Can I take Lopinavir with Lurasidone?
MediHelp rates the interaction as contraindicated. Lopinavir and Lurasidone are not normally used together. Taking them at the same time is expected to cause harm or make one of them unsafe, so a different medicine is usually chosen for one of the two. Lopinavir is co-formulated with ritonavir, a strong CYP3A4 inhibitor, and is expected to raise lurasidone exposure considerably. This increases the risk of sedation, extrapyramidal symptoms and other dose-related toxicity. The combination is contraindicated.
How serious is the interaction between Lopinavir and Lurasidone?
MediHelp rates it contraindicated, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Do not coadminister; choose an antipsychotic less dependent on CYP3A4 or a different antiretroviral.
What other medicines interact with Lurasidone?
MediHelp also lists interactions of Lurasidone with, for example, Apalutamide, Atazanavir, Carbamazepine. The full list is on the Lurasidone page.
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