Drug interactions
Lopinavir + Rimegepant
Severity: Major
Lopinavir and Rimegepant: major interaction.
Last updated Sources: US FDA label
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Lopinavir, which is given with ritonavir, inhibits CYP3A4 and P-glycoprotein and may raise rimegepant exposure markedly. Adverse effects of rimegepant could increase.
What this interaction means in plain words
Lopinavir and Rimegepant can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Lopinavir belongs to Anti Virals; Rimegepant belongs to Central Nervous System.
Why it happens
Inhibition of CYP3A4 and P-glycoprotein by lopinavir/ritonavir, reducing rimegepant clearance.
What to do
Avoid the combination and use an alternative acute migraine therapy.
What to ask your pharmacist
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
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References
Other interactions of Rimegepant
Other interactions of Lopinavir
- Alfuzosin + Lopinavir Contraindicated
- Avanafil + Lopinavir Contraindicated
- Cisapride + Lopinavir Contraindicated
- Dronedarone + Lopinavir Contraindicated
- Eletriptan + Lopinavir Contraindicated
- Eplerenone + Lopinavir Contraindicated
Frequently asked questions
Can I take Lopinavir with Rimegepant?
MediHelp rates the interaction as major. Lopinavir and Rimegepant can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Lopinavir, which is given with ritonavir, inhibits CYP3A4 and P-glycoprotein and may raise rimegepant exposure markedly. Adverse effects of rimegepant could increase.
How serious is the interaction between Lopinavir and Rimegepant?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid the combination and use an alternative acute migraine therapy.
What other medicines interact with Rimegepant?
MediHelp also lists interactions of Rimegepant with, for example, Amobarbital, Atazanavir, Butabarbital. The full list is on the Rimegepant page.
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