Drug interactions
Lopinavir + Solifenacin
Severity: Major
Lopinavir and Solifenacin: major interaction.
Last updated Sources: US FDA label
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Ritonavir-boosted lopinavir inhibits CYP3A4 and can increase solifenacin levels. Both drugs can also prolong the QT interval, so the arrhythmia risk is compounded.
What this interaction means in plain words
Lopinavir and Solifenacin can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Lopinavir belongs to Anti Virals; Solifenacin belongs to Genitourinary.
Why it happens
CYP3A4 inhibition raises solifenacin exposure, with additive QT prolongation.
What to do
Limit solifenacin to 5 mg daily and monitor ECG and electrolytes. Consider an alternative agent in patients with other QT risk factors.
What to ask your pharmacist
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
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References
Other interactions of Solifenacin
Other interactions of Lopinavir
- Alfuzosin + Lopinavir Contraindicated
- Avanafil + Lopinavir Contraindicated
- Cisapride + Lopinavir Contraindicated
- Dronedarone + Lopinavir Contraindicated
- Eletriptan + Lopinavir Contraindicated
- Eplerenone + Lopinavir Contraindicated
Frequently asked questions
Can I take Lopinavir with Solifenacin?
MediHelp rates the interaction as major. Lopinavir and Solifenacin can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Ritonavir-boosted lopinavir inhibits CYP3A4 and can increase solifenacin levels. Both drugs can also prolong the QT interval, so the arrhythmia risk is compounded.
How serious is the interaction between Lopinavir and Solifenacin?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Limit solifenacin to 5 mg daily and monitor ECG and electrolytes. Consider an alternative agent in patients with other QT risk factors.
What other medicines interact with Solifenacin?
MediHelp also lists interactions of Solifenacin with, for example, Adagrasib, Amiodarone, Amisulpride. The full list is on the Solifenacin page.
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