Drug interactions
Loratadine + Midazolam
Severity: Minor
Loratadine and Midazolam: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Loratadine is a non-sedating antihistamine at usual doses, so any added sedation with midazolam is small. Some patients may notice mild additional drowsiness.
What this interaction means in plain words
Loratadine and Midazolam have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Loratadine belongs to Respiratory; Midazolam belongs to Central Nervous System.
Why it happens
Possible slight additive CNS depression; loratadine penetrates the brain poorly.
What to do
No dose change is normally needed; observe for unexpected drowsiness after midazolam.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Midazolam
- Atazanavir + Midazolam Contraindicated
- Cobicistat + Midazolam Contraindicated
- Darunavir + Midazolam Contraindicated
- Elvitegravir / cobicistat / emtricitabine / tenofovir df + Midazolam Contraindicated
- Fosamprenavir + Midazolam Contraindicated
- Indinavir + Midazolam Contraindicated
Other interactions of Loratadine
- Acrivastine + Loratadine Moderate
- Amobarbital + Loratadine Moderate
- Fentanyl + Loratadine Moderate
- Isocarboxazid + Loratadine Moderate
- Levoketoconazole + Loratadine Moderate
- Loratadine + Mavacamten Moderate
Frequently asked questions
Can I take Loratadine with Midazolam?
MediHelp rates the interaction as minor. Loratadine and Midazolam have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Loratadine is a non-sedating antihistamine at usual doses, so any added sedation with midazolam is small. Some patients may notice mild additional drowsiness.
How serious is the interaction between Loratadine and Midazolam?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: No dose change is normally needed; observe for unexpected drowsiness after midazolam.
What other medicines interact with Midazolam?
MediHelp also lists interactions of Midazolam with, for example, Atazanavir, Cobicistat, Darunavir. The full list is on the Midazolam page.
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