Drug interactions
Loratadine + Tacrolimus
Severity: Minor
Loratadine and Tacrolimus: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Loratadine may inhibit P-glycoprotein and could slightly raise tacrolimus levels. Because tacrolimus has a narrow therapeutic index, any increase could contribute to nephrotoxicity or neurotoxicity, though clinical evidence is lacking.
What this interaction means in plain words
Loratadine and Tacrolimus have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Loratadine belongs to Respiratory; Tacrolimus belongs to Miscellaneous.
Why it happens
Possible P-glycoprotein inhibition by loratadine reduces tacrolimus efflux.
What to do
Maintain standard tacrolimus trough monitoring and check a level if loratadine is started or stopped.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Loratadine
- Acrivastine + Loratadine Moderate
- Amobarbital + Loratadine Moderate
- Fentanyl + Loratadine Moderate
- Isocarboxazid + Loratadine Moderate
- Levoketoconazole + Loratadine Moderate
- Loratadine + Mavacamten Moderate
Other interactions of Tacrolimus
- Adenovirus types 4 and 7 live + Tacrolimus Contraindicated
- Bcg vaccine live + Tacrolimus Contraindicated
- Cidofovir + Tacrolimus Contraindicated
- Cyclosporin + Tacrolimus Contraindicated
- Influenza virus vaccine quadrivalent intranasal + Tacrolimus Contraindicated
- Measles mumps and rubella vaccine live + Tacrolimus Contraindicated
Frequently asked questions
Can I take Loratadine with Tacrolimus?
MediHelp rates the interaction as minor. Loratadine and Tacrolimus have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Loratadine may inhibit P-glycoprotein and could slightly raise tacrolimus levels. Because tacrolimus has a narrow therapeutic index, any increase could contribute to nephrotoxicity or neurotoxicity, though clinical evidence is lacking.
How serious is the interaction between Loratadine and Tacrolimus?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Maintain standard tacrolimus trough monitoring and check a level if loratadine is started or stopped.
What other medicines interact with Loratadine?
MediHelp also lists interactions of Loratadine with, for example, Acrivastine, Amobarbital, Fentanyl. The full list is on the Loratadine page.
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