Drug interactions
Loratadine + Voriconazole
Severity: Moderate
Loratadine and Voriconazole: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Voriconazole strongly inhibits CYP3A4 and may raise loratadine concentrations. Loratadine has a wide safety margin and the increase is generally well tolerated, though sedation or QT concerns are theoretical.
What this interaction means in plain words
Loratadine and Voriconazole can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Loratadine belongs to Respiratory; Voriconazole belongs to Anti Fungals.
Why it happens
Voriconazole inhibits CYP3A4 (and CYP2C19), decreasing loratadine metabolism.
What to do
Monitor for sedation and palpitations, and consider fexofenadine or a standard-dose alternative if symptoms appear.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Loratadine
- Acrivastine + Loratadine Moderate
- Amobarbital + Loratadine Moderate
- Fentanyl + Loratadine Moderate
- Isocarboxazid + Loratadine Moderate
- Levoketoconazole + Loratadine Moderate
- Loratadine + Mavacamten Moderate
Other interactions of Voriconazole
- Avanafil + Voriconazole Contraindicated
- Butabarbital + Voriconazole Contraindicated
- Carbamazepine + Voriconazole Contraindicated
- Conivaptan + Voriconazole Contraindicated
- Dihydroergotamine intranasal + Voriconazole Contraindicated
- Dihydroergotamine + Voriconazole Contraindicated
Frequently asked questions
Can I take Loratadine with Voriconazole?
MediHelp rates the interaction as moderate. Loratadine and Voriconazole can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Voriconazole strongly inhibits CYP3A4 and may raise loratadine concentrations. Loratadine has a wide safety margin and the increase is generally well tolerated, though sedation or QT concerns are theoretical.
How serious is the interaction between Loratadine and Voriconazole?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor for sedation and palpitations, and consider fexofenadine or a standard-dose alternative if symptoms appear.
What other medicines interact with Loratadine?
MediHelp also lists interactions of Loratadine with, for example, Acrivastine, Amobarbital, Fentanyl. The full list is on the Loratadine page.
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