Drug interactions
Lorlatinib + Rolapitant
Severity: Minor
Lorlatinib and Rolapitant: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Lorlatinib is a moderate CYP3A4 inducer, and rolapitant is metabolized partly by CYP3A4. Rolapitant exposure may fall, possibly reducing its antiemetic effect, though the effect has not been well characterized.
What this interaction means in plain words
Lorlatinib and Rolapitant have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Lorlatinib belongs to Oncology; Rolapitant belongs to Gastrointestinal Tract.
Why it happens
Lorlatinib induces CYP3A4, which may increase rolapitant metabolism.
What to do
No dose adjustment is usually needed. Monitor for breakthrough nausea and vomiting and add other antiemetics if needed.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Rolapitant
- Pimozide + Rolapitant Contraindicated
- Rolapitant + Thioridazine Contraindicated
- Atomoxetine + Rolapitant Major
- Deutetrabenazine + Rolapitant Major
- Eliglustat + Rolapitant Major
- Flecainide + Rolapitant Major
Other interactions of Lorlatinib
- Amobarbital + Lorlatinib Contraindicated
- Apalutamide + Lorlatinib Contraindicated
- Butabarbital + Lorlatinib Contraindicated
- Carbamazepine + Lorlatinib Contraindicated
- Enzalutamide + Lorlatinib Contraindicated
- Fosphenytoin + Lorlatinib Contraindicated
Frequently asked questions
Can I take Lorlatinib with Rolapitant?
MediHelp rates the interaction as minor. Lorlatinib and Rolapitant have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Lorlatinib is a moderate CYP3A4 inducer, and rolapitant is metabolized partly by CYP3A4. Rolapitant exposure may fall, possibly reducing its antiemetic effect, though the effect has not been well characterized.
How serious is the interaction between Lorlatinib and Rolapitant?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: No dose adjustment is usually needed. Monitor for breakthrough nausea and vomiting and add other antiemetics if needed.
What other medicines interact with Rolapitant?
MediHelp also lists interactions of Rolapitant with, for example, Pimozide, Thioridazine, Atomoxetine. The full list is on the Rolapitant page.
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