Drug interactions
Lornoxicam + Metolazone
Severity: Moderate
Lornoxicam and Metolazone: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
NSAIDs such as lornoxicam can blunt the diuretic and antihypertensive effect of metolazone and may impair renal function, particularly in volume-depleted patients. Combined use also raises the risk of acute kidney injury.
What this interaction means in plain words
Lornoxicam and Metolazone can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Lornoxicam belongs to Musculoskeletal; Metolazone belongs to Cardiovascular.
Why it happens
NSAID inhibition of renal prostaglandin synthesis causes sodium and water retention and reduced renal perfusion, opposing diuretic action.
What to do
Monitor blood pressure, fluid status, serum creatinine and electrolytes, and use the lowest effective NSAID dose for the shortest time. Consider a non-NSAID analgesic where possible.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Metolazone
Other interactions of Lornoxicam
Frequently asked questions
Can I take Lornoxicam with Metolazone?
MediHelp rates the interaction as moderate. Lornoxicam and Metolazone can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. NSAIDs such as lornoxicam can blunt the diuretic and antihypertensive effect of metolazone and may impair renal function, particularly in volume-depleted patients. Combined use also raises the risk of acute kidney injury.
How serious is the interaction between Lornoxicam and Metolazone?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor blood pressure, fluid status, serum creatinine and electrolytes, and use the lowest effective NSAID dose for the shortest time. Consider a non-NSAID analgesic where possible.
What other medicines interact with Metolazone?
MediHelp also lists interactions of Metolazone with, for example, Amifostine, Amlodipine-hydrochlorothiazide-valsartan, Amlodipine-olmesartan-hydrochlorothiazide. The full list is on the Metolazone page.
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