Drug interactions
Lornoxicam + Sotalol
Severity: Moderate
Lornoxicam and Sotalol: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Prolonged NSAID use can blunt the blood pressure lowering effect of beta-blockers such as sotalol. NSAIDs can also reduce renal function and cause fluid retention, which may raise sotalol exposure since it is renally cleared and increase proarrhythmic risk.
What this interaction means in plain words
Lornoxicam and Sotalol can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Lornoxicam belongs to Musculoskeletal; Sotalol belongs to Cardiovascular.
Why it happens
NSAID inhibition of prostaglandin synthesis causes sodium and water retention and reduced renal perfusion, opposing the antihypertensive effect and potentially reducing sotalol clearance.
What to do
Monitor blood pressure and renal function when lornoxicam is used for more than a few days with sotalol. Use the lowest effective dose for the shortest time, or consider paracetamol.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Sotalol
- Arsenic trioxide + Sotalol Contraindicated
- Artemether / lumefantrine + Sotalol Contraindicated
- Disopyramide + Sotalol Contraindicated
- Dofetilide + Sotalol Contraindicated
- Dronedarone + Sotalol Contraindicated
- Droperidol + Sotalol Contraindicated
Other interactions of Lornoxicam
Frequently asked questions
Can I take Lornoxicam with Sotalol?
MediHelp rates the interaction as moderate. Lornoxicam and Sotalol can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Prolonged NSAID use can blunt the blood pressure lowering effect of beta-blockers such as sotalol. NSAIDs can also reduce renal function and cause fluid retention, which may raise sotalol exposure since it is renally cleared and increase proarrhythmic risk.
How serious is the interaction between Lornoxicam and Sotalol?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor blood pressure and renal function when lornoxicam is used for more than a few days with sotalol. Use the lowest effective dose for the shortest time, or consider paracetamol.
What other medicines interact with Sotalol?
MediHelp also lists interactions of Sotalol with, for example, Arsenic trioxide, Artemether / lumefantrine, Disopyramide. The full list is on the Sotalol page.
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