Drug interactions
Lornoxicam + Trazodone
Severity: Moderate
Lornoxicam and Trazodone: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Trazodone has serotonergic activity that impairs platelet aggregation, and lornoxicam is an NSAID that irritates the gastric mucosa and inhibits platelet function. Together they raise the risk of gastrointestinal and other bleeding.
What this interaction means in plain words
Lornoxicam and Trazodone can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Lornoxicam belongs to Musculoskeletal; Trazodone belongs to Central Nervous System.
Why it happens
Additive impairment of platelet function (reduced platelet serotonin uptake plus NSAID COX inhibition) together with NSAID mucosal injury.
What to do
Monitor for signs of GI bleeding such as melena or anemia, and use the lowest effective NSAID dose for the shortest time. Consider gastroprotection with a proton pump inhibitor in patients at higher risk.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Trazodone
- Arsenic trioxide + Trazodone Contraindicated
- Ibutilide + Trazodone Contraindicated
- Isocarboxazid + Trazodone Contraindicated
- Levoketoconazole + Trazodone Contraindicated
- Methylene blue + Trazodone Contraindicated
- Phenelzine + Trazodone Contraindicated
Other interactions of Lornoxicam
Frequently asked questions
Can I take Lornoxicam with Trazodone?
MediHelp rates the interaction as moderate. Lornoxicam and Trazodone can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Trazodone has serotonergic activity that impairs platelet aggregation, and lornoxicam is an NSAID that irritates the gastric mucosa and inhibits platelet function. Together they raise the risk of gastrointestinal and other bleeding.
How serious is the interaction between Lornoxicam and Trazodone?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor for signs of GI bleeding such as melena or anemia, and use the lowest effective NSAID dose for the shortest time. Consider gastroprotection with a proton pump inhibitor in patients at higher risk.
What other medicines interact with Trazodone?
MediHelp also lists interactions of Trazodone with, for example, Arsenic trioxide, Ibutilide, Isocarboxazid. The full list is on the Trazodone page.
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