Drug interactions
Lovastatin + Nevirapine
Severity: Moderate
Lovastatin and Nevirapine: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Nevirapine can lower lovastatin and active metabolite concentrations, reducing cholesterol-lowering effect. Lipid control may be inadequate unless the dose is adjusted.
What this interaction means in plain words
Lovastatin and Nevirapine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Lovastatin belongs to Cardiovascular; Nevirapine belongs to Anti Virals.
Why it happens
Nevirapine induces intestinal and hepatic CYP3A4, increasing lovastatin first-pass metabolism.
What to do
Monitor the lipid profile and increase the lovastatin dose as needed within the maximum dose. Consider a statin less dependent on CYP3A4, such as rosuvastatin or pravastatin.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Nevirapine
- Elbasvir / grazoprevir + Nevirapine Contraindicated
- Nevirapine + Ranolazine Contraindicated
- Nevirapine + St john's wort Contraindicated
- Abemaciclib + Nevirapine Major
- Acalabrutinib + Nevirapine Major
- Amobarbital + Nevirapine Major
Other interactions of Lovastatin
- Atazanavir + Lovastatin Contraindicated
- Clarithromycin + Lovastatin Contraindicated
- Cobicistat + Lovastatin Contraindicated
- Conivaptan + Lovastatin Contraindicated
- Darunavir + Lovastatin Contraindicated
- Elvitegravir / cobicistat / emtricitabine / tenofovir df + Lovastatin Contraindicated
Frequently asked questions
Can I take Lovastatin with Nevirapine?
MediHelp rates the interaction as moderate. Lovastatin and Nevirapine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Nevirapine can lower lovastatin and active metabolite concentrations, reducing cholesterol-lowering effect. Lipid control may be inadequate unless the dose is adjusted.
How serious is the interaction between Lovastatin and Nevirapine?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor the lipid profile and increase the lovastatin dose as needed within the maximum dose. Consider a statin less dependent on CYP3A4, such as rosuvastatin or pravastatin.
What other medicines interact with Nevirapine?
MediHelp also lists interactions of Nevirapine with, for example, Elbasvir / grazoprevir, Ranolazine, St john's wort. The full list is on the Nevirapine page.
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