Drug interactions
Lovastatin + Ranolazine
Severity: Moderate
Lovastatin and Ranolazine: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Ranolazine inhibits CYP3A4 and P-glycoprotein, and lovastatin is sensitive to CYP3A4 so its exposure can rise, increasing the risk of myopathy. Labeling advises limiting the dose of lovastatin when used with ranolazine.
What this interaction means in plain words
Lovastatin and Ranolazine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Lovastatin belongs to Cardiovascular; Ranolazine belongs to Cardiovascular.
Why it happens
Ranolazine inhibits CYP3A4 and P-glycoprotein, reducing lovastatin clearance.
What to do
Limit the lovastatin dose as stated in product labeling when ranolazine is used, or switch to a statin less dependent on CYP3A4. Counsel patients to report muscle pain or weakness.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Ranolazine
- Adagrasib + Ranolazine Contraindicated
- Amobarbital + Ranolazine Contraindicated
- Apalutamide + Ranolazine Contraindicated
- Butabarbital + Ranolazine Contraindicated
- Carbamazepine + Ranolazine Contraindicated
- Clarithromycin + Ranolazine Contraindicated
Other interactions of Lovastatin
- Atazanavir + Lovastatin Contraindicated
- Clarithromycin + Lovastatin Contraindicated
- Cobicistat + Lovastatin Contraindicated
- Conivaptan + Lovastatin Contraindicated
- Darunavir + Lovastatin Contraindicated
- Elvitegravir / cobicistat / emtricitabine / tenofovir df + Lovastatin Contraindicated
Frequently asked questions
Can I take Lovastatin with Ranolazine?
MediHelp rates the interaction as moderate. Lovastatin and Ranolazine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Ranolazine inhibits CYP3A4 and P-glycoprotein, and lovastatin is sensitive to CYP3A4 so its exposure can rise, increasing the risk of myopathy. Labeling advises limiting the dose of lovastatin when used with ranolazine.
How serious is the interaction between Lovastatin and Ranolazine?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Limit the lovastatin dose as stated in product labeling when ranolazine is used, or switch to a statin less dependent on CYP3A4. Counsel patients to report muscle pain or weakness.
What other medicines interact with Ranolazine?
MediHelp also lists interactions of Ranolazine with, for example, Adagrasib, Amobarbital, Apalutamide. The full list is on the Ranolazine page.
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