Drug interactions
Lovastatin + Stiripentol
Severity: Moderate
Lovastatin and Stiripentol: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Stiripentol inhibits and induces CYP3A4 and inhibits P-glycoprotein, so lovastatin exposure may change unpredictably, with a possible increase. Higher levels would raise the risk of statin-related muscle toxicity, while induction could reduce efficacy.
What this interaction means in plain words
Lovastatin and Stiripentol can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Lovastatin belongs to Cardiovascular; Stiripentol belongs to Central Nervous System.
Why it happens
Mixed CYP3A4 inhibition/induction and P-gp inhibition alter lovastatin disposition.
What to do
Monitor lipid response and muscle symptoms, adjusting the lovastatin dose accordingly. Consider a non-CYP3A4 statin if problems arise.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Lovastatin
- Atazanavir + Lovastatin Contraindicated
- Clarithromycin + Lovastatin Contraindicated
- Cobicistat + Lovastatin Contraindicated
- Conivaptan + Lovastatin Contraindicated
- Darunavir + Lovastatin Contraindicated
- Elvitegravir / cobicistat / emtricitabine / tenofovir df + Lovastatin Contraindicated
Other interactions of Stiripentol
Frequently asked questions
Can I take Lovastatin with Stiripentol?
MediHelp rates the interaction as moderate. Lovastatin and Stiripentol can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Stiripentol inhibits and induces CYP3A4 and inhibits P-glycoprotein, so lovastatin exposure may change unpredictably, with a possible increase. Higher levels would raise the risk of statin-related muscle toxicity, while induction could reduce efficacy.
How serious is the interaction between Lovastatin and Stiripentol?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor lipid response and muscle symptoms, adjusting the lovastatin dose accordingly. Consider a non-CYP3A4 statin if problems arise.
What other medicines interact with Lovastatin?
MediHelp also lists interactions of Lovastatin with, for example, Atazanavir, Clarithromycin, Cobicistat. The full list is on the Lovastatin page.
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