Drug interactions
Loxapine + Propofol
Severity: Moderate
Loxapine and Propofol: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Loxapine can enhance the sedative and hypotensive effects of propofol, potentially causing deeper anesthesia or sedation than expected. Respiratory depression and hypotension may be more pronounced.
What this interaction means in plain words
Loxapine and Propofol can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Loxapine belongs to Central Nervous System; Propofol belongs to Central Nervous System.
Why it happens
Additive CNS depression and additive hypotensive effects via alpha-1 blockade.
What to do
Titrate propofol carefully, usually at a reduced dose, and monitor airway, oxygenation, and blood pressure. Ensure the anesthesia team knows about the antipsychotic.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
Pro+ members
Unlock the full page
Create an account and start a Pro+ trial to unlock the full management advice for Loxapine and Propofol, the additional notes, the evidence detail and the whole-prescription interaction checker.
- Full clinical management advice
- Additional notes
- Evidence detail
- Interaction checker for a whole prescription
Try Pro+ free for 7 days on the web. No card needed.
Other interactions of Loxapine
- Alfentanil + Loxapine Major
- Alprazolam + Loxapine Major
- Amisulpride + Loxapine Major
- Amoxapine + Loxapine Major
- Apomorphine + Loxapine Major
- Belladonna and opium + Loxapine Major
Other interactions of Propofol
Frequently asked questions
Can I take Loxapine with Propofol?
MediHelp rates the interaction as moderate. Loxapine and Propofol can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Loxapine can enhance the sedative and hypotensive effects of propofol, potentially causing deeper anesthesia or sedation than expected. Respiratory depression and hypotension may be more pronounced.
How serious is the interaction between Loxapine and Propofol?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Titrate propofol carefully, usually at a reduced dose, and monitor airway, oxygenation, and blood pressure. Ensure the anesthesia team knows about the antipsychotic.
What other medicines interact with Loxapine?
MediHelp also lists interactions of Loxapine with, for example, Alfentanil, Alprazolam, Amisulpride. The full list is on the Loxapine page.
Full monographs, dosing and an interaction checker in the MediHelp app
Open the complete reference, check multi-drug interactions and use dosing tools in the MediHelp app.
