Drug interactions
Loxapine + Vilazodone
Severity: Moderate
Loxapine and Vilazodone: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Loxapine blocks dopamine and serotonin receptors, and combined with vilazodone it may raise the risk of neuroleptic malignant syndrome or serotonin syndrome. These events are uncommon but serious.
What this interaction means in plain words
Loxapine and Vilazodone can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Loxapine belongs to Central Nervous System; Vilazodone belongs to Central Nervous System.
Why it happens
Additive serotonergic activity with dopamine D2 antagonism, a pharmacodynamic interaction.
What to do
Monitor for hyperthermia, rigidity, clonus, tremor and autonomic instability when starting or adjusting either drug. Discontinue both and provide supportive care if toxicity occurs.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Vilazodone
- Isocarboxazid + Vilazodone Contraindicated
- Methylene blue + Vilazodone Contraindicated
- Phenelzine + Vilazodone Contraindicated
- Rasagiline + Vilazodone Contraindicated
- Selegiline transdermal + Vilazodone Contraindicated
- Selegiline + Vilazodone Contraindicated
Other interactions of Loxapine
- Alfentanil + Loxapine Major
- Alprazolam + Loxapine Major
- Amisulpride + Loxapine Major
- Amoxapine + Loxapine Major
- Apomorphine + Loxapine Major
- Belladonna and opium + Loxapine Major
Frequently asked questions
Can I take Loxapine with Vilazodone?
MediHelp rates the interaction as moderate. Loxapine and Vilazodone can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Loxapine blocks dopamine and serotonin receptors, and combined with vilazodone it may raise the risk of neuroleptic malignant syndrome or serotonin syndrome. These events are uncommon but serious.
How serious is the interaction between Loxapine and Vilazodone?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor for hyperthermia, rigidity, clonus, tremor and autonomic instability when starting or adjusting either drug. Discontinue both and provide supportive care if toxicity occurs.
What other medicines interact with Vilazodone?
MediHelp also lists interactions of Vilazodone with, for example, Isocarboxazid, Methylene blue, Phenelzine. The full list is on the Vilazodone page.
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