Drug interactions
Lurasidone + Metolazone
Severity: Moderate
Lurasidone and Metolazone: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Lurasidone can cause orthostatic hypotension through alpha-1 blockade, which may add to the blood pressure lowering of metolazone. Dizziness and falls are the main concerns, especially in older or volume-depleted patients.
What this interaction means in plain words
Lurasidone and Metolazone can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Lurasidone belongs to Central Nervous System; Metolazone belongs to Cardiovascular.
Why it happens
Additive hypotensive effects: alpha-adrenergic blockade from lurasidone plus diuretic-induced volume depletion.
What to do
Monitor blood pressure and orthostatic symptoms, particularly during initiation and dose increases. Reduce the antihypertensive dose if hypotension develops.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Metolazone
Other interactions of Lurasidone
- Apalutamide + Lurasidone Contraindicated
- Atazanavir + Lurasidone Contraindicated
- Carbamazepine + Lurasidone Contraindicated
- Clarithromycin + Lurasidone Contraindicated
- Cobicistat + Lurasidone Contraindicated
- Conivaptan + Lurasidone Contraindicated
Frequently asked questions
Can I take Lurasidone with Metolazone?
MediHelp rates the interaction as moderate. Lurasidone and Metolazone can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Lurasidone can cause orthostatic hypotension through alpha-1 blockade, which may add to the blood pressure lowering of metolazone. Dizziness and falls are the main concerns, especially in older or volume-depleted patients.
How serious is the interaction between Lurasidone and Metolazone?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor blood pressure and orthostatic symptoms, particularly during initiation and dose increases. Reduce the antihypertensive dose if hypotension develops.
What other medicines interact with Metolazone?
MediHelp also lists interactions of Metolazone with, for example, Amifostine, Amlodipine-hydrochlorothiazide-valsartan, Amlodipine-olmesartan-hydrochlorothiazide. The full list is on the Metolazone page.
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