Drug interactions
Lurasidone + Mirtazapine
Severity: Minor
Lurasidone and Mirtazapine: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Both drugs act on the central nervous system and may produce additive sedation or dizziness. They are sometimes combined intentionally in depression and psychosis without significant pharmacokinetic interaction.
What this interaction means in plain words
Lurasidone and Mirtazapine have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Lurasidone belongs to Central Nervous System; Mirtazapine belongs to Central Nervous System.
Why it happens
Additive CNS effects; no significant pharmacokinetic interaction is established.
What to do
Monitor for sedation and orthostatic dizziness during initiation and dose changes. No dose adjustment is routinely needed.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Mirtazapine
- Isocarboxazid + Mirtazapine Contraindicated
- Mirtazapine + Phenelzine Contraindicated
- Mirtazapine + Pimozide Contraindicated
- Mirtazapine + Procarbazine Contraindicated
- Mirtazapine + Rasagiline Contraindicated
- Mirtazapine + Selegiline Contraindicated
Other interactions of Lurasidone
- Apalutamide + Lurasidone Contraindicated
- Atazanavir + Lurasidone Contraindicated
- Carbamazepine + Lurasidone Contraindicated
- Clarithromycin + Lurasidone Contraindicated
- Cobicistat + Lurasidone Contraindicated
- Conivaptan + Lurasidone Contraindicated
Frequently asked questions
Can I take Lurasidone with Mirtazapine?
MediHelp rates the interaction as minor. Lurasidone and Mirtazapine have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Both drugs act on the central nervous system and may produce additive sedation or dizziness. They are sometimes combined intentionally in depression and psychosis without significant pharmacokinetic interaction.
How serious is the interaction between Lurasidone and Mirtazapine?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor for sedation and orthostatic dizziness during initiation and dose changes. No dose adjustment is routinely needed.
What other medicines interact with Mirtazapine?
MediHelp also lists interactions of Mirtazapine with, for example, Isocarboxazid, Phenelzine, Pimozide. The full list is on the Mirtazapine page.
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