Drug interactions
Lurasidone + Oxycodone
Severity: Moderate
Lurasidone and Oxycodone: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Both drugs cause sedation, so concurrent use can increase drowsiness, dizziness, orthostatic hypotension and impaired psychomotor function. Respiratory depression is less likely but possible at higher opioid doses. Lurasidone is a CYP3A4 substrate, but oxycodone does not meaningfully affect it.
What this interaction means in plain words
Lurasidone and Oxycodone can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Lurasidone belongs to Central Nervous System; Oxycodone belongs to Musculoskeletal.
Why it happens
Additive CNS depressant effects of the opioid and the antipsychotic.
What to do
Use the lowest effective oxycodone dose and monitor for sedation and orthostatic hypotension. Counsel patients about driving and operating machinery.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Oxycodone
- Alvimopan + Oxycodone Contraindicated
- Calcium / magnesium / potassium / sodium oxybates + Oxycodone Contraindicated
- Isocarboxazid + Oxycodone Contraindicated
- Olanzapine / samidorphan + Oxycodone Contraindicated
- Oxycodone + Phenelzine Contraindicated
- Oxycodone + Sodium oxybate Contraindicated
Other interactions of Lurasidone
- Apalutamide + Lurasidone Contraindicated
- Atazanavir + Lurasidone Contraindicated
- Carbamazepine + Lurasidone Contraindicated
- Clarithromycin + Lurasidone Contraindicated
- Cobicistat + Lurasidone Contraindicated
- Conivaptan + Lurasidone Contraindicated
Frequently asked questions
Can I take Lurasidone with Oxycodone?
MediHelp rates the interaction as moderate. Lurasidone and Oxycodone can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Both drugs cause sedation, so concurrent use can increase drowsiness, dizziness, orthostatic hypotension and impaired psychomotor function. Respiratory depression is less likely but possible at higher opioid doses. Lurasidone is a CYP3A4 substrate, but oxycodone does not meaningfully affect it.
How serious is the interaction between Lurasidone and Oxycodone?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Use the lowest effective oxycodone dose and monitor for sedation and orthostatic hypotension. Counsel patients about driving and operating machinery.
What other medicines interact with Oxycodone?
MediHelp also lists interactions of Oxycodone with, for example, Alvimopan, Calcium / magnesium / potassium / sodium oxybates, Isocarboxazid. The full list is on the Oxycodone page.
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