Drug interactions
Lurasidone + Pregabalin
Severity: Moderate
Lurasidone and Pregabalin: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Both drugs can cause somnolence, dizziness and impaired concentration, so combined use may intensify these effects. Pregabalin has been associated with additive CNS impairment when combined with other CNS depressants.
What this interaction means in plain words
Lurasidone and Pregabalin can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Lurasidone belongs to Central Nervous System; Pregabalin belongs to Central Nervous System.
Why it happens
Additive CNS depressant effects; no significant pharmacokinetic interaction.
What to do
Titrate pregabalin cautiously and monitor for sedation, dizziness and falls, advising patients to avoid driving until the response is known.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Lurasidone
- Apalutamide + Lurasidone Contraindicated
- Atazanavir + Lurasidone Contraindicated
- Carbamazepine + Lurasidone Contraindicated
- Clarithromycin + Lurasidone Contraindicated
- Cobicistat + Lurasidone Contraindicated
- Conivaptan + Lurasidone Contraindicated
Other interactions of Pregabalin
Frequently asked questions
Can I take Lurasidone with Pregabalin?
MediHelp rates the interaction as moderate. Lurasidone and Pregabalin can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Both drugs can cause somnolence, dizziness and impaired concentration, so combined use may intensify these effects. Pregabalin has been associated with additive CNS impairment when combined with other CNS depressants.
How serious is the interaction between Lurasidone and Pregabalin?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Titrate pregabalin cautiously and monitor for sedation, dizziness and falls, advising patients to avoid driving until the response is known.
What other medicines interact with Lurasidone?
MediHelp also lists interactions of Lurasidone with, for example, Apalutamide, Atazanavir, Carbamazepine. The full list is on the Lurasidone page.
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