Drug interactions
Lurasidone + Ranolazine
Severity: Moderate
Lurasidone and Ranolazine: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Ranolazine is a weak CYP3A4 inhibitor and may modestly raise lurasidone concentrations. This could increase sedation, akathisia, extrapyramidal symptoms or other dose-related effects.
What this interaction means in plain words
Lurasidone and Ranolazine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Lurasidone belongs to Central Nervous System; Ranolazine belongs to Cardiovascular.
Why it happens
Weak CYP3A4 inhibition by ranolazine reduces lurasidone metabolism.
What to do
Monitor for increased lurasidone adverse effects after ranolazine is started. Reduce the lurasidone dose if adverse effects occur.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Ranolazine
- Adagrasib + Ranolazine Contraindicated
- Amobarbital + Ranolazine Contraindicated
- Apalutamide + Ranolazine Contraindicated
- Butabarbital + Ranolazine Contraindicated
- Carbamazepine + Ranolazine Contraindicated
- Clarithromycin + Ranolazine Contraindicated
Other interactions of Lurasidone
- Apalutamide + Lurasidone Contraindicated
- Atazanavir + Lurasidone Contraindicated
- Carbamazepine + Lurasidone Contraindicated
- Clarithromycin + Lurasidone Contraindicated
- Cobicistat + Lurasidone Contraindicated
- Conivaptan + Lurasidone Contraindicated
Frequently asked questions
Can I take Lurasidone with Ranolazine?
MediHelp rates the interaction as moderate. Lurasidone and Ranolazine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Ranolazine is a weak CYP3A4 inhibitor and may modestly raise lurasidone concentrations. This could increase sedation, akathisia, extrapyramidal symptoms or other dose-related effects.
How serious is the interaction between Lurasidone and Ranolazine?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor for increased lurasidone adverse effects after ranolazine is started. Reduce the lurasidone dose if adverse effects occur.
What other medicines interact with Ranolazine?
MediHelp also lists interactions of Ranolazine with, for example, Adagrasib, Amobarbital, Apalutamide. The full list is on the Ranolazine page.
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