Drug interactions
Lurasidone + Stiripentol
Severity: Moderate
Lurasidone and Stiripentol: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Stiripentol can both inhibit and induce CYP3A4, so lurasidone exposure may change unpredictably, with a risk of reduced efficacy or increased adverse effects. Both drugs also cause sedation and somnolence. Lurasidone labeling advises against use with strong CYP3A4 inducers, and stiripentol's net effect is mixed.
What this interaction means in plain words
Lurasidone and Stiripentol can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Lurasidone belongs to Central Nervous System; Stiripentol belongs to Central Nervous System.
Why it happens
Mixed CYP3A4 inhibition and induction by stiripentol altering lurasidone metabolism, plus additive CNS depression.
What to do
Monitor psychiatric response and adverse effects such as sedation and akathisia after starting or stopping stiripentol. Adjust the lurasidone dose based on clinical response.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Lurasidone
- Apalutamide + Lurasidone Contraindicated
- Atazanavir + Lurasidone Contraindicated
- Carbamazepine + Lurasidone Contraindicated
- Clarithromycin + Lurasidone Contraindicated
- Cobicistat + Lurasidone Contraindicated
- Conivaptan + Lurasidone Contraindicated
Other interactions of Stiripentol
Frequently asked questions
Can I take Lurasidone with Stiripentol?
MediHelp rates the interaction as moderate. Lurasidone and Stiripentol can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Stiripentol can both inhibit and induce CYP3A4, so lurasidone exposure may change unpredictably, with a risk of reduced efficacy or increased adverse effects. Both drugs also cause sedation and somnolence. Lurasidone labeling advises against use with strong CYP3A4 inducers, and stiripentol's net effect is mixed.
How serious is the interaction between Lurasidone and Stiripentol?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor psychiatric response and adverse effects such as sedation and akathisia after starting or stopping stiripentol. Adjust the lurasidone dose based on clinical response.
What other medicines interact with Lurasidone?
MediHelp also lists interactions of Lurasidone with, for example, Apalutamide, Atazanavir, Carbamazepine. The full list is on the Lurasidone page.
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