Drug interactions
Lurasidone + Trimipramine
Severity: Moderate
Lurasidone and Trimipramine: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Both drugs can cause sedation and orthostatic hypotension through alpha-1 blockade, so the combination may increase dizziness and fall risk. Trimipramine may also modestly affect lurasidone exposure and add to overall CNS depression.
What this interaction means in plain words
Lurasidone and Trimipramine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Lurasidone belongs to Central Nervous System; Trimipramine belongs to Central Nervous System.
Why it happens
Additive CNS depressant and alpha-1 adrenergic blocking effects.
What to do
Monitor blood pressure and sedation, especially during initiation and dose changes. Advise patients to rise slowly and avoid driving until tolerance is known.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Trimipramine
- Disopyramide + Trimipramine Contraindicated
- Dofetilide + Trimipramine Contraindicated
- Ibutilide + Trimipramine Contraindicated
- Isocarboxazid + Trimipramine Contraindicated
- Pentamidine + Trimipramine Contraindicated
- Phenelzine + Trimipramine Contraindicated
Other interactions of Lurasidone
- Apalutamide + Lurasidone Contraindicated
- Atazanavir + Lurasidone Contraindicated
- Carbamazepine + Lurasidone Contraindicated
- Clarithromycin + Lurasidone Contraindicated
- Cobicistat + Lurasidone Contraindicated
- Conivaptan + Lurasidone Contraindicated
Frequently asked questions
Can I take Lurasidone with Trimipramine?
MediHelp rates the interaction as moderate. Lurasidone and Trimipramine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Both drugs can cause sedation and orthostatic hypotension through alpha-1 blockade, so the combination may increase dizziness and fall risk. Trimipramine may also modestly affect lurasidone exposure and add to overall CNS depression.
How serious is the interaction between Lurasidone and Trimipramine?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor blood pressure and sedation, especially during initiation and dose changes. Advise patients to rise slowly and avoid driving until tolerance is known.
What other medicines interact with Trimipramine?
MediHelp also lists interactions of Trimipramine with, for example, Disopyramide, Dofetilide, Ibutilide. The full list is on the Trimipramine page.
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