Drug interactions
Lurasidone + Vigabatrin
Severity: Moderate
Lurasidone and Vigabatrin: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Both drugs can cause somnolence and fatigue, so concurrent use may increase sedation and impaired alertness. Vigabatrin may also cause psychiatric effects such as psychosis and depression that could complicate management of the underlying illness.
What this interaction means in plain words
Lurasidone and Vigabatrin can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Lurasidone belongs to Central Nervous System; Vigabatrin belongs to Central Nervous System.
Why it happens
Additive pharmacodynamic CNS depressant effects.
What to do
Monitor for sedation and changes in mental status or mood, and counsel patients about driving and hazardous tasks.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Lurasidone
- Apalutamide + Lurasidone Contraindicated
- Atazanavir + Lurasidone Contraindicated
- Carbamazepine + Lurasidone Contraindicated
- Clarithromycin + Lurasidone Contraindicated
- Cobicistat + Lurasidone Contraindicated
- Conivaptan + Lurasidone Contraindicated
Other interactions of Vigabatrin
- Amisulpride + Vigabatrin Moderate
- Asenapine transdermal + Vigabatrin Moderate
- Asenapine + Vigabatrin Moderate
- Avapritinib + Vigabatrin Moderate
- Benzhydrocodone / acetaminophen + Vigabatrin Moderate
- Brexanolone + Vigabatrin Moderate
Frequently asked questions
Can I take Lurasidone with Vigabatrin?
MediHelp rates the interaction as moderate. Lurasidone and Vigabatrin can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Both drugs can cause somnolence and fatigue, so concurrent use may increase sedation and impaired alertness. Vigabatrin may also cause psychiatric effects such as psychosis and depression that could complicate management of the underlying illness.
How serious is the interaction between Lurasidone and Vigabatrin?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor for sedation and changes in mental status or mood, and counsel patients about driving and hazardous tasks.
What other medicines interact with Lurasidone?
MediHelp also lists interactions of Lurasidone with, for example, Apalutamide, Atazanavir, Carbamazepine. The full list is on the Lurasidone page.
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