Drug interactions
Lurbinectedin + Posaconazole
Severity: Major
Lurbinectedin and Posaconazole: major interaction.
Last updated Sources: EMA SmPC
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Lurbinectedin is cleared mainly by CYP3A4, so posaconazole can raise its exposure. This increases the risk of myelosuppression and hepatotoxicity.
What this interaction means in plain words
Lurbinectedin and Posaconazole can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Lurbinectedin belongs to Oncology; Posaconazole belongs to Anti Fungals.
Why it happens
Strong CYP3A4 inhibition reduces lurbinectedin clearance.
What to do
Avoid the combination if possible. If it is unavoidable, reduce the lurbinectedin dose by 50% and monitor blood counts and liver tests, restoring the dose after the inhibitor has been stopped for about 5 half-lives.
What to ask your pharmacist
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
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References
Other interactions of Posaconazole
- Artemether + Posaconazole Contraindicated
- Avanafil + Posaconazole Contraindicated
- Cobimetinib + Posaconazole Contraindicated
- Conivaptan + Posaconazole Contraindicated
- Dihydroergotamine intranasal + Posaconazole Contraindicated
- Dihydroergotamine + Posaconazole Contraindicated
Other interactions of Lurbinectedin
Frequently asked questions
Can I take Lurbinectedin with Posaconazole?
MediHelp rates the interaction as major. Lurbinectedin and Posaconazole can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Lurbinectedin is cleared mainly by CYP3A4, so posaconazole can raise its exposure. This increases the risk of myelosuppression and hepatotoxicity.
How serious is the interaction between Lurbinectedin and Posaconazole?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid the combination if possible. If it is unavoidable, reduce the lurbinectedin dose by 50% and monitor blood counts and liver tests, restoring the dose after the inhibitor has been stopped for about 5 half-lives.
What other medicines interact with Posaconazole?
MediHelp also lists interactions of Posaconazole with, for example, Artemether, Avanafil, Cobimetinib. The full list is on the Posaconazole page.
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