Drug interactions
Macimorelin + Mirtazapine
Severity: Moderate
Macimorelin and Mirtazapine: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Macimorelin can prolong the QT interval, and mirtazapine has additional QT liability. Test results and cardiac safety may be affected.
What this interaction means in plain words
Macimorelin and Mirtazapine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Macimorelin belongs to Endocrine; Mirtazapine belongs to Central Nervous System.
Why it happens
Additive prolongation of cardiac repolarization.
What to do
Consider withholding mirtazapine before the single-dose test if clinically acceptable, and avoid testing in patients with QT risk factors.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Mirtazapine
- Isocarboxazid + Mirtazapine Contraindicated
- Mirtazapine + Phenelzine Contraindicated
- Mirtazapine + Pimozide Contraindicated
- Mirtazapine + Procarbazine Contraindicated
- Mirtazapine + Rasagiline Contraindicated
- Mirtazapine + Selegiline Contraindicated
Other interactions of Macimorelin
Frequently asked questions
Can I take Macimorelin with Mirtazapine?
MediHelp rates the interaction as moderate. Macimorelin and Mirtazapine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Macimorelin can prolong the QT interval, and mirtazapine has additional QT liability. Test results and cardiac safety may be affected.
How serious is the interaction between Macimorelin and Mirtazapine?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Consider withholding mirtazapine before the single-dose test if clinically acceptable, and avoid testing in patients with QT risk factors.
What other medicines interact with Mirtazapine?
MediHelp also lists interactions of Mirtazapine with, for example, Isocarboxazid, Phenelzine, Pimozide. The full list is on the Mirtazapine page.
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