Drug interactions
Macimorelin + Nevirapine
Severity: Moderate
Macimorelin and Nevirapine: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Strong CYP3A4 inducers may lower macimorelin exposure and affect the growth hormone stimulation test. Nevirapine is a CYP3A inducer, so the test results may be unreliable.
What this interaction means in plain words
Macimorelin and Nevirapine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Macimorelin belongs to Endocrine; Nevirapine belongs to Anti Virals.
Why it happens
Nevirapine induces CYP3A4, which may reduce macimorelin concentrations.
What to do
Avoid testing while on nevirapine if possible, allowing adequate washout. Otherwise interpret the result with caution.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Nevirapine
- Elbasvir / grazoprevir + Nevirapine Contraindicated
- Nevirapine + Ranolazine Contraindicated
- Nevirapine + St john's wort Contraindicated
- Abemaciclib + Nevirapine Major
- Acalabrutinib + Nevirapine Major
- Amobarbital + Nevirapine Major
Other interactions of Macimorelin
Frequently asked questions
Can I take Macimorelin with Nevirapine?
MediHelp rates the interaction as moderate. Macimorelin and Nevirapine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Strong CYP3A4 inducers may lower macimorelin exposure and affect the growth hormone stimulation test. Nevirapine is a CYP3A inducer, so the test results may be unreliable.
How serious is the interaction between Macimorelin and Nevirapine?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid testing while on nevirapine if possible, allowing adequate washout. Otherwise interpret the result with caution.
What other medicines interact with Nevirapine?
MediHelp also lists interactions of Nevirapine with, for example, Elbasvir / grazoprevir, Ranolazine, St john's wort. The full list is on the Nevirapine page.
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