Drug interactions
Macimorelin + Ranolazine
Severity: Major
Macimorelin and Ranolazine: major interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Macimorelin has a modest QTc-prolonging effect, and ranolazine also prolongs QTc. Using them together may increase the risk of torsades de pointes.
What this interaction means in plain words
Macimorelin and Ranolazine can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Macimorelin belongs to Endocrine; Ranolazine belongs to Cardiovascular.
Why it happens
Additive pharmacodynamic prolongation of the QT interval.
What to do
Withhold ranolazine for an adequate washout period before the macimorelin test, or use an alternative diagnostic approach. Check ECG if concurrent use cannot be avoided.
What to ask your pharmacist
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
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Other interactions of Ranolazine
- Adagrasib + Ranolazine Contraindicated
- Amobarbital + Ranolazine Contraindicated
- Apalutamide + Ranolazine Contraindicated
- Butabarbital + Ranolazine Contraindicated
- Carbamazepine + Ranolazine Contraindicated
- Clarithromycin + Ranolazine Contraindicated
Other interactions of Macimorelin
Frequently asked questions
Can I take Macimorelin with Ranolazine?
MediHelp rates the interaction as major. Macimorelin and Ranolazine can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Macimorelin has a modest QTc-prolonging effect, and ranolazine also prolongs QTc. Using them together may increase the risk of torsades de pointes.
How serious is the interaction between Macimorelin and Ranolazine?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Withhold ranolazine for an adequate washout period before the macimorelin test, or use an alternative diagnostic approach. Check ECG if concurrent use cannot be avoided.
What other medicines interact with Ranolazine?
MediHelp also lists interactions of Ranolazine with, for example, Adagrasib, Amobarbital, Apalutamide. The full list is on the Ranolazine page.
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