Drug interactions
Macimorelin + Risperidone
Severity: Moderate
Macimorelin and Risperidone: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Macimorelin causes a small QT prolongation, and risperidone may add to this. The combination may increase the risk of torsades de pointes during the stimulation test.
What this interaction means in plain words
Macimorelin and Risperidone can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Macimorelin belongs to Endocrine; Risperidone belongs to Central Nervous System.
Why it happens
Additive QT prolongation.
What to do
Use an alternative diagnostic or allow adequate washout of risperidone before testing where clinically feasible. Otherwise monitor ECG during testing.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Risperidone
- Ibutilide + Risperidone Contraindicated
- Risperidone + Vandetanib Contraindicated
- Adagrasib + Risperidone Major
- Amiodarone + Risperidone Major
- Amisulpride + Risperidone Major
- Amoxapine + Risperidone Major
Other interactions of Macimorelin
Frequently asked questions
Can I take Macimorelin with Risperidone?
MediHelp rates the interaction as moderate. Macimorelin and Risperidone can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Macimorelin causes a small QT prolongation, and risperidone may add to this. The combination may increase the risk of torsades de pointes during the stimulation test.
How serious is the interaction between Macimorelin and Risperidone?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Use an alternative diagnostic or allow adequate washout of risperidone before testing where clinically feasible. Otherwise monitor ECG during testing.
What other medicines interact with Risperidone?
MediHelp also lists interactions of Risperidone with, for example, Ibutilide, Vandetanib, Adagrasib. The full list is on the Risperidone page.
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