Drug interactions
Macimorelin + Sevoflurane
Severity: Moderate
Macimorelin and Sevoflurane: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Macimorelin has a labeled QT prolongation effect, and sevoflurane may add to it. Because macimorelin is given as a single diagnostic dose, exposure is brief but overlap with anesthesia could still raise arrhythmia risk.
What this interaction means in plain words
Macimorelin and Sevoflurane can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Macimorelin belongs to Endocrine; Sevoflurane belongs to Central Nervous System.
Why it happens
Additive delay of cardiac repolarization.
What to do
Do not schedule macimorelin testing close to general anesthesia with sevoflurane. If both are unavoidable, monitor the ECG and keep electrolytes within normal range.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Sevoflurane
Other interactions of Macimorelin
Frequently asked questions
Can I take Macimorelin with Sevoflurane?
MediHelp rates the interaction as moderate. Macimorelin and Sevoflurane can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Macimorelin has a labeled QT prolongation effect, and sevoflurane may add to it. Because macimorelin is given as a single diagnostic dose, exposure is brief but overlap with anesthesia could still raise arrhythmia risk.
How serious is the interaction between Macimorelin and Sevoflurane?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Do not schedule macimorelin testing close to general anesthesia with sevoflurane. If both are unavoidable, monitor the ECG and keep electrolytes within normal range.
What other medicines interact with Sevoflurane?
MediHelp also lists interactions of Sevoflurane with, for example, Amiodarone, Amisulpride, Arsenic trioxide. The full list is on the Sevoflurane page.
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