Drug interactions
Macimorelin + Sotalol
Severity: Major
Macimorelin and Sotalol: major interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Macimorelin causes a modest QT prolongation, and sotalol adds to this effect. Because macimorelin is a single-dose diagnostic, exposure is brief but torsades risk is still raised.
What this interaction means in plain words
Macimorelin and Sotalol can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Macimorelin belongs to Endocrine; Sotalol belongs to Cardiovascular.
Why it happens
Additive pharmacodynamic QT prolongation.
What to do
Avoid macimorelin testing in patients on sotalol, or use another diagnostic approach for growth hormone deficiency. If testing is essential, allow adequate washout of sotalol when safe and monitor ECG.
What to ask your pharmacist
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
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Other interactions of Sotalol
- Arsenic trioxide + Sotalol Contraindicated
- Artemether / lumefantrine + Sotalol Contraindicated
- Disopyramide + Sotalol Contraindicated
- Dofetilide + Sotalol Contraindicated
- Dronedarone + Sotalol Contraindicated
- Droperidol + Sotalol Contraindicated
Other interactions of Macimorelin
Frequently asked questions
Can I take Macimorelin with Sotalol?
MediHelp rates the interaction as major. Macimorelin and Sotalol can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Macimorelin causes a modest QT prolongation, and sotalol adds to this effect. Because macimorelin is a single-dose diagnostic, exposure is brief but torsades risk is still raised.
How serious is the interaction between Macimorelin and Sotalol?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid macimorelin testing in patients on sotalol, or use another diagnostic approach for growth hormone deficiency. If testing is essential, allow adequate washout of sotalol when safe and monitor ECG.
What other medicines interact with Sotalol?
MediHelp also lists interactions of Sotalol with, for example, Arsenic trioxide, Artemether / lumefantrine, Disopyramide. The full list is on the Sotalol page.
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