Drug interactions
Macimorelin + Trimipramine
Severity: Moderate
Macimorelin and Trimipramine: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Macimorelin causes a modest QT increase and trimipramine can also prolong QT, so the combination may raise the risk of torsades de pointes. Macimorelin is used as a single-dose diagnostic test, so exposure is short.
What this interaction means in plain words
Macimorelin and Trimipramine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Macimorelin belongs to Endocrine; Trimipramine belongs to Central Nervous System.
Why it happens
Additive QT prolongation.
What to do
Withhold trimipramine for an adequate washout period before the test where clinically feasible, or defer testing. If coadministered, consider ECG monitoring.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Trimipramine
- Disopyramide + Trimipramine Contraindicated
- Dofetilide + Trimipramine Contraindicated
- Ibutilide + Trimipramine Contraindicated
- Isocarboxazid + Trimipramine Contraindicated
- Pentamidine + Trimipramine Contraindicated
- Phenelzine + Trimipramine Contraindicated
Other interactions of Macimorelin
Frequently asked questions
Can I take Macimorelin with Trimipramine?
MediHelp rates the interaction as moderate. Macimorelin and Trimipramine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Macimorelin causes a modest QT increase and trimipramine can also prolong QT, so the combination may raise the risk of torsades de pointes. Macimorelin is used as a single-dose diagnostic test, so exposure is short.
How serious is the interaction between Macimorelin and Trimipramine?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Withhold trimipramine for an adequate washout period before the test where clinically feasible, or defer testing. If coadministered, consider ECG monitoring.
What other medicines interact with Trimipramine?
MediHelp also lists interactions of Trimipramine with, for example, Disopyramide, Dofetilide, Ibutilide. The full list is on the Trimipramine page.
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