Drug interactions
Magnesium hydroxide + Metolazone
Severity: Minor
Magnesium hydroxide and Metolazone: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Metolazone promotes urinary magnesium wasting and may cause hypomagnesemia, especially with prolonged use or combined with loop diuretics. The effect on magnesium from occasional magnesium hydroxide is small.
What this interaction means in plain words
Magnesium hydroxide and Metolazone have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Magnesium hydroxide belongs to Gastrointestinal Tract; Metolazone belongs to Cardiovascular.
Why it happens
Metolazone inhibits distal tubular sodium-chloride transport, increasing renal magnesium loss.
What to do
No routine action is needed for occasional use. Monitor serum magnesium and potassium during continued metolazone therapy.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Magnesium hydroxide
Other interactions of Metolazone
Frequently asked questions
Can I take Magnesium hydroxide with Metolazone?
MediHelp rates the interaction as minor. Magnesium hydroxide and Metolazone have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Metolazone promotes urinary magnesium wasting and may cause hypomagnesemia, especially with prolonged use or combined with loop diuretics. The effect on magnesium from occasional magnesium hydroxide is small.
How serious is the interaction between Magnesium hydroxide and Metolazone?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: No routine action is needed for occasional use. Monitor serum magnesium and potassium during continued metolazone therapy.
What other medicines interact with Magnesium hydroxide?
MediHelp also lists interactions of Magnesium hydroxide with, for example, Ciprofloxacin, Dolutegravir, Gemifloxacin. The full list is on the Magnesium hydroxide page.
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