Drug interactions
Magnesium hydroxide + Vitamin d
Severity: Moderate
Magnesium hydroxide and Vitamin d: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Vitamin D enhances intestinal magnesium absorption, and magnesium is cleared by the kidney. In patients with renal impairment, the combination can lead to hypermagnesemia with weakness, hypotension, and cardiac or respiratory depression.
What this interaction means in plain words
Magnesium hydroxide and Vitamin d can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Magnesium hydroxide belongs to Gastrointestinal Tract; Vitamin d belongs to Gastrointestinal Tract.
Why it happens
Vitamin D increases intestinal magnesium absorption, and reduced renal clearance allows accumulation.
What to do
Avoid regular magnesium-containing antacids or laxatives in chronic kidney disease patients taking vitamin D. Monitor serum magnesium if combined use is necessary.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Magnesium hydroxide
Other interactions of Vitamin d
Frequently asked questions
Can I take Magnesium hydroxide with Vitamin d?
MediHelp rates the interaction as moderate. Magnesium hydroxide and Vitamin d can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Vitamin D enhances intestinal magnesium absorption, and magnesium is cleared by the kidney. In patients with renal impairment, the combination can lead to hypermagnesemia with weakness, hypotension, and cardiac or respiratory depression.
How serious is the interaction between Magnesium hydroxide and Vitamin d?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid regular magnesium-containing antacids or laxatives in chronic kidney disease patients taking vitamin D. Monitor serum magnesium if combined use is necessary.
What other medicines interact with Magnesium hydroxide?
MediHelp also lists interactions of Magnesium hydroxide with, for example, Ciprofloxacin, Dolutegravir, Gemifloxacin. The full list is on the Magnesium hydroxide page.
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