Drug interactions
Magnesium oxide + Metolazone
Severity: Minor
Magnesium oxide and Metolazone: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Metolazone increases urinary magnesium loss and can cause hypomagnesemia, which magnesium supplementation may counter. This is more a therapeutic offset than a harmful interaction.
What this interaction means in plain words
Magnesium oxide and Metolazone have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Magnesium oxide belongs to Gastrointestinal Tract; Metolazone belongs to Cardiovascular.
Why it happens
Metolazone increases renal magnesium excretion, opposing magnesium supplementation.
What to do
Monitor serum magnesium and adjust supplementation if levels remain low.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Metolazone
Other interactions of Magnesium oxide
- Chloroquine + Magnesium oxide Moderate
- Ciprofloxacin + Magnesium oxide Moderate
- Dolutegravir + Magnesium oxide Moderate
- Doxycycline + Magnesium oxide Moderate
- Eltrombopag + Magnesium oxide Moderate
- Gemifloxacin + Magnesium oxide Moderate
Frequently asked questions
Can I take Magnesium oxide with Metolazone?
MediHelp rates the interaction as minor. Magnesium oxide and Metolazone have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Metolazone increases urinary magnesium loss and can cause hypomagnesemia, which magnesium supplementation may counter. This is more a therapeutic offset than a harmful interaction.
How serious is the interaction between Magnesium oxide and Metolazone?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor serum magnesium and adjust supplementation if levels remain low.
What other medicines interact with Metolazone?
MediHelp also lists interactions of Metolazone with, for example, Amifostine, Amlodipine-hydrochlorothiazide-valsartan, Amlodipine-olmesartan-hydrochlorothiazide. The full list is on the Metolazone page.
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