Drug interactions
Magnesium sulphate + Mannitol
Severity: Minor
Magnesium sulphate and Mannitol: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Osmotic diuresis from mannitol increases urinary excretion of electrolytes including magnesium. Large or repeated doses may lower serum magnesium and reduce the effect of magnesium therapy.
What this interaction means in plain words
Magnesium sulphate and Mannitol have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Magnesium sulphate belongs to Cardiovascular; Mannitol belongs to Cardiovascular.
Why it happens
Osmotic diuresis increases renal magnesium excretion.
What to do
Monitor serum electrolytes including magnesium when repeated mannitol doses are given and replace deficits.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Magnesium sulphate
- Amikacin + Magnesium sulphate Moderate
- Amphotericin b deoxycholate + Magnesium sulphate Moderate
- Atracurium + Magnesium sulphate Moderate
- Baloxavir marboxil + Magnesium sulphate Moderate
- Ciprofloxacin + Magnesium sulphate Moderate
- Cisatracurium + Magnesium sulphate Moderate
Other interactions of Mannitol
Frequently asked questions
Can I take Magnesium sulphate with Mannitol?
MediHelp rates the interaction as minor. Magnesium sulphate and Mannitol have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Osmotic diuresis from mannitol increases urinary excretion of electrolytes including magnesium. Large or repeated doses may lower serum magnesium and reduce the effect of magnesium therapy.
How serious is the interaction between Magnesium sulphate and Mannitol?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor serum electrolytes including magnesium when repeated mannitol doses are given and replace deficits.
What other medicines interact with Magnesium sulphate?
MediHelp also lists interactions of Magnesium sulphate with, for example, Amikacin, Amphotericin b deoxycholate, Atracurium. The full list is on the Magnesium sulphate page.
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