Drug interactions
Mannitol + Verteporfin
Severity: Minor
Mannitol and Verteporfin: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Mannitol is a hydroxyl radical scavenger and may in theory reduce the cytotoxic effect of the singlet oxygen and radicals generated by activated verteporfin. This could reduce the therapeutic effect of photodynamic therapy.
What this interaction means in plain words
Mannitol and Verteporfin have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Mannitol belongs to Cardiovascular; Verteporfin belongs to Miscellaneous.
Why it happens
Scavenging of reactive oxygen species generated during photoactivation of verteporfin.
What to do
Avoid giving mannitol around the time of verteporfin infusion and light activation unless it is clinically required. Monitor the treatment response.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Verteporfin
- Doxycycline + Verteporfin Moderate
- Griseofulvin + Verteporfin Moderate
- Minocycline + Verteporfin Moderate
- Tetracycline + Verteporfin Moderate
- Adapalene + Verteporfin Minor
- Amlodipine-hydrochlorothiazide-valsartan + Verteporfin Minor
Other interactions of Mannitol
Frequently asked questions
Can I take Mannitol with Verteporfin?
MediHelp rates the interaction as minor. Mannitol and Verteporfin have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Mannitol is a hydroxyl radical scavenger and may in theory reduce the cytotoxic effect of the singlet oxygen and radicals generated by activated verteporfin. This could reduce the therapeutic effect of photodynamic therapy.
How serious is the interaction between Mannitol and Verteporfin?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid giving mannitol around the time of verteporfin infusion and light activation unless it is clinically required. Monitor the treatment response.
What other medicines interact with Verteporfin?
MediHelp also lists interactions of Verteporfin with, for example, Doxycycline, Griseofulvin, Minocycline. The full list is on the Verteporfin page.
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