Drug interactions
Maprotiline + Metoclopramide
Severity: Moderate
Maprotiline and Metoclopramide: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Maprotiline is a tetracyclic antidepressant that can cause sedation and has antidopaminergic and anticholinergic effects at higher exposures. Combined with metoclopramide, a dopamine antagonist, the risk of extrapyramidal symptoms and sedation may increase, and antimuscarinic effects may blunt metoclopramide's prokinetic action.
What this interaction means in plain words
Maprotiline and Metoclopramide can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Maprotiline belongs to Central Nervous System; Metoclopramide belongs to Gastrointestinal Tract.
Why it happens
Additive central dopamine antagonism and CNS depression, with opposing anticholinergic effects on gastrointestinal motility.
What to do
Monitor for extrapyramidal symptoms, sedation and reduced antiemetic or prokinetic response, and use the lowest effective metoclopramide dose for the shortest time. Consider a different antiemetic if movement symptoms appear.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Metoclopramide
Other interactions of Maprotiline
- Arsenic trioxide + Maprotiline Contraindicated
- Disopyramide + Maprotiline Contraindicated
- Dofetilide + Maprotiline Contraindicated
- Ibutilide + Maprotiline Contraindicated
- Isocarboxazid + Maprotiline Contraindicated
- Maprotiline + Methylene blue Contraindicated
Frequently asked questions
Can I take Maprotiline with Metoclopramide?
MediHelp rates the interaction as moderate. Maprotiline and Metoclopramide can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Maprotiline is a tetracyclic antidepressant that can cause sedation and has antidopaminergic and anticholinergic effects at higher exposures. Combined with metoclopramide, a dopamine antagonist, the risk of extrapyramidal symptoms and sedation may increase, and antimuscarinic effects may blunt metoclopramide's prokinetic action.
How serious is the interaction between Maprotiline and Metoclopramide?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor for extrapyramidal symptoms, sedation and reduced antiemetic or prokinetic response, and use the lowest effective metoclopramide dose for the shortest time. Consider a different antiemetic if movement symptoms appear.
What other medicines interact with Metoclopramide?
MediHelp also lists interactions of Metoclopramide with, for example, Amantadine, Amoxapine, Antipsychotics (e.g., haloperidol). The full list is on the Metoclopramide page.
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