Drug interactions
Maprotiline + Progesterone
Severity: Minor
Maprotiline and Progesterone: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Sex steroid hormones have been reported to alter the response to tricyclic-type antidepressants, with possible changes in antidepressant effect and in drug exposure. Evidence for progesterone specifically is sparse and the clinical effect is probably small.
What this interaction means in plain words
Maprotiline and Progesterone have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Maprotiline belongs to Central Nervous System; Progesterone belongs to Endocrine.
Why it happens
The mechanism is not well established; hormonal modulation of hepatic metabolism of the antidepressant has been proposed.
What to do
No routine change is needed; if antidepressant response changes or anticholinergic or cardiac adverse effects appear after hormone therapy is started or stopped, reassess the maprotiline dose.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Progesterone
Other interactions of Maprotiline
- Arsenic trioxide + Maprotiline Contraindicated
- Disopyramide + Maprotiline Contraindicated
- Dofetilide + Maprotiline Contraindicated
- Ibutilide + Maprotiline Contraindicated
- Isocarboxazid + Maprotiline Contraindicated
- Maprotiline + Methylene blue Contraindicated
Frequently asked questions
Can I take Maprotiline with Progesterone?
MediHelp rates the interaction as minor. Maprotiline and Progesterone have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Sex steroid hormones have been reported to alter the response to tricyclic-type antidepressants, with possible changes in antidepressant effect and in drug exposure. Evidence for progesterone specifically is sparse and the clinical effect is probably small.
How serious is the interaction between Maprotiline and Progesterone?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: No routine change is needed; if antidepressant response changes or anticholinergic or cardiac adverse effects appear after hormone therapy is started or stopped, reassess the maprotiline dose.
What other medicines interact with Progesterone?
MediHelp also lists interactions of Progesterone with, for example, Apalutamide, Carbamazepine, Enzalutamide. The full list is on the Progesterone page.
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