Drug interactions
Maprotiline + Propofol
Severity: Moderate
Maprotiline and Propofol: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Maprotiline can add to the sedative and hypotensive effects of propofol, and may also lower seizure threshold or contribute to arrhythmia risk. Anesthetic requirements may be reduced, and recovery may be prolonged.
What this interaction means in plain words
Maprotiline and Propofol can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Maprotiline belongs to Central Nervous System; Propofol belongs to Central Nervous System.
Why it happens
Additive CNS depression and cardiovascular effects.
What to do
Titrate propofol to effect with continuous hemodynamic and ECG monitoring. Inform the anesthesia team about maprotiline use before procedures.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Maprotiline
- Arsenic trioxide + Maprotiline Contraindicated
- Disopyramide + Maprotiline Contraindicated
- Dofetilide + Maprotiline Contraindicated
- Ibutilide + Maprotiline Contraindicated
- Isocarboxazid + Maprotiline Contraindicated
- Maprotiline + Methylene blue Contraindicated
Other interactions of Propofol
Frequently asked questions
Can I take Maprotiline with Propofol?
MediHelp rates the interaction as moderate. Maprotiline and Propofol can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Maprotiline can add to the sedative and hypotensive effects of propofol, and may also lower seizure threshold or contribute to arrhythmia risk. Anesthetic requirements may be reduced, and recovery may be prolonged.
How serious is the interaction between Maprotiline and Propofol?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Titrate propofol to effect with continuous hemodynamic and ECG monitoring. Inform the anesthesia team about maprotiline use before procedures.
What other medicines interact with Maprotiline?
MediHelp also lists interactions of Maprotiline with, for example, Arsenic trioxide, Disopyramide, Dofetilide. The full list is on the Maprotiline page.
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